Sp1 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comSp1 Polyclonal Antibody for Rat(Rattus norvegicus)

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Index > Protein center > Sp1(Gene name) > Rat

Sp1 (Gene name),

Transcription factor Sp1 (Protein name ), SP1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Sp1;

Protein name:

Transcription factor Sp1;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1 (By similarity). Interacts with SMARCA4/BRG1. Interacts with ATF7IP and TBP(By similarity).

Function:

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression (By similarity). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter.

Subcellular Location:

Nucleus Cytoplasm Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.

Protein Attributes:

Sequence length:

786

Sequence:

50:

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300:

350:

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450:

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650:

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750:

786:

AMEAICPEGI | ARLANSGINV | MQVTELQSIN | ISGNGF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q01714

KEGG:

rno:24790

SMR:

Q01714

Pfam:

PF00096

UniGene:

Rn.44609

Uniprot:

Q01714

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ELISA Kit for Rat Transcription factor Sp1

Cat.:

E15093r

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Rat Transcription factor Sp1

Cat.:

E15093m

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MSDS:

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Packing:

96T

ELISA Kit for Rat Transcription factor Sp1

Cat.:

E15093h

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Manual:

Looking for manual.

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Packing:

96T

Range:

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CLIA Kit for Rat Transcription factor Sp1

Cat.:

U15093h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Transcription factor Sp1

Cat.:

U15093m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Transcription factor Sp1

Cat.:

U15093r

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Transcription factor Sp1

Cat.:

P15093Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Transcription factor Sp1

Cat.:

P15093Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Transcription factor Sp1

Cat.:

P15093Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Transcription factor Sp1

Protein for Rat Transcription factor Sp1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene."
Imataka H. , Sogawa K. , Yasumoto K. , Kikuchi Y. , Sasano K. , Kobayashi A. , Hayami M. , Fujii-Kuriyama Y.
EMBO J.11:3663-3671(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Liver.
2.

"The trans-spliced variants of Sp1 mRNA in rat."
Takahara T. , Kasahara D. , Mori D. , Yanagisawa S. , Akanuma H.
Biochem. Biophys. Res. Commun.298:156-162(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-559;TISSUE SPECIFICITY
tissue: Liver.
3.

"A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression."
Qiu Z. , Ghosh A.
Neuron60:775-787(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMARCA4/BRG1

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